Design, synthesis, and potential CNS activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-methyl-4H-quinazolin-3-yl)-urea

SK Kashaw, V Kashaw, P Mishra, NK Jain…

Index: Kashaw, Sushil K.; Kashaw, Varsha; Mishra, Pradeep; Jain; Stables Medicinal Chemistry Research, 2011 , vol. 20, # 6 p. 738 - 745

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Citation Number: 3

Abstract

Abstract Twelve new 1-(4-substituted-phenyl)-3-(4-oxo-2-methyl-4H-quinazolin-3-yl)-urea were synthesized and screened for anticonvulsant, CNS depressant, and sedative-hypnotic activity. After ip injection to mice at doses of 30, 100, and 300 mg/kg body weight 2, 3- Disubstituted-quinazolin-4 (3H)-one were examined in the maximal electroshock-induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in ...