Synthesis and biological activities of novel artemisinin derivatives as cysteine protease falcipain-2 inhibitors

…, WQ Lu, KQ Cui, W Luo, J Wang, C Guo

Index: Liu, Yang; Lu, Wei-Qiang; Cui, Kun-Qiang; Luo, Wei; Wang, Jian; Guo, Chun Archives of Pharmacal Research, 2012 , vol. 35, # 9 p. 1525 - 1531

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Citation Number: 8

Abstract

Abstract A series of novel artemisinin derivatives were synthesized from artemisinin and different anilines. All compounds were obtained as β-isomers. The target compounds were evaluated for inhibition activity against Plasmodium falciparum falcipain-2 in vitro, and most of them exhibited potent inhibition in the low micromolar range and proved to be new types of falcipain-2 inhibitors.