A novel palladium-catalyzed cycloalkylation to isoxazoline 2-oxides. Application for the asymmetric synthesis of carbanucleosides.

BM Trost, L Li, SD Guile

Index: Trost; Li; Guile Journal of the American Chemical Society, 1992 , vol. 114, # 22 p. 8745 - 8747

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Citation Number: 144

Abstract

The slow protonation rates we have observed suggest that proton transfers could be rate-determining in the action of oxo-bridged ... (16) Espenson, J. H. Chemical Kinetics and Reaction Mechanisms; McGraw-Hill: New York, NY, 1981; p 67. (17) Kolthoff, 1. M.; Bruckenstein, S.; Chantooni, MK J. Am. Chem. SOC. 1961,83, 3927. (18) The pK, is calculated from the spectrophotometrically measured equilibrium constant for 3 + lutidinium + 3H+ + lutidine as in ref 8b. (19) pK, = ...

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