Journal of molecular biology

Structure and engineering of L-arabinitol 4-dehydrogenase from Neurospora crassa

B Bae, RP Sullivan, H Zhao, SK Nair

Index: Bae, Brian; Sullivan, Ryan P.; Zhao, Huimin; Nair, Satish K. Journal of Molecular Biology, 2010 , vol. 402, # 1 p. 230 - 240

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Citation Number: 9

Abstract

l-Arabinitol 4-dehydrogenase (LAD) catalyzes the conversion of l-arabinitol into l-xylulose with concomitant NAD+ reduction. It is an essential enzyme in the development of recombinant organisms that convert l-arabinose into fuels and chemicals using the fungal l- arabinose catabolic pathway. Here we report the crystal structure of LAD from the filamentous fungus Neurospora crassa at 2.6 Å resolution. In addition, we created a ...

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