Journal of the Chemical Society, Perkin Transactions 1

1-Substituted 2′-deoxyinosine analogues

LD Napoli

Index: De Napoli, Lorenzo; Messere, Anna; Montesarchio, Daniela; Piccialli, Gennaro; Varra, Michela Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 14 p. 2079 - 2082

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Citation Number: 28

Abstract

The base 2-carbon of 2′, 3′-di-O-acetyl-2′-deoxyinosine is strongly activated towards nucleophilic attack when either the 4-nitrophenyl or 2, 4-dinitrophenyl group is attached to its N-1 position (product 1 or 2). 1-(ω-Aminoalkyl)-and 1-(ω-hydroxyalkyl)-2′-deoxyinosine derivatives 5, 8–10 have been efficiently synthesized by a rearrangement of the purine ring upon treatment of compound 1 or 2 with the appropriate α, ω-diamine or α, ω- ...

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