Novel and convenient aldolization of methyl 3, 3, 3-trifluoropyruvate using enamines instead of ketones

J Paleček, O Paleta

Index: Palecek, Jiri; Paleta, Oldrich Synthesis, 2004 , # 4 p. 521 - 524

Full Text: HTML

Citation Number: 11

Abstract

Abstract Piperidine enamines derived from acetone, acetophenone, cyclopentanone and cyclohexanone react easily in minutes with methyl 3, 3, 3-trifluoropyruvate (1) to afford products of the aldol condensation in high yields at room temperature, which is in contrast to the direct aldolization of 1 with the ketones.