Chemistry Letters

PEPTIDE SYNTHESIS BY USING PHENYLPHOSPHONIC ESTER AS A COUPLING REAGENT

Y Watanabe, N Morito, K Kamekawa, T Mukaiyama

Index: Watanabe, Yutaka; Morito, Naoya; Kamekawa, Ken-ichi; Mukaiyama, Teruaki Chemistry Letters, 1981 , p. 65 - 68

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Citation Number: 6

Abstract

Synthesis of peptides containing various functions was efficiently accomplished by treatment of the tetrabutylammonium salts of N-protected amino acids (or peptides) with amino acid esters in the presence of bis (o-or p-nitrophenyl) phenylphosphonate. Synthesis of leucine- enkephalin was successfully achieved by the above method employing a (3+ 2) or (4+ 1) fragment coupling approach.