4, 4-disubstituted piperidines: a new class of NK1 antagonists

GI Stevenson, AM MacLeod, I Huscroft…

Index: Stevenson; MacLeod; Huscroft; Cascieri; Sadowski; Baker Journal of Medicinal Chemistry, 1995 , vol. 38, # 8 p. 1264 - 1266

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Citation Number: 29

Abstract

The recent discovery of selective non-peptide substance P antagonists, such as CP-96,345 (1), l together with the availability of the cloned human NK1 receptor2 has led to an intense exploration of the pharmacology of substance P. Subsequently, several non-peptide antagonists from structurally different classes have been identified, including the quinuclidinium-based SR 140333 (2), 3 piperidine CP 99,994 (3), 4 the tryptophan L- ...