Synthesis of cephapirin and related cephalosporins from 7-(. alpha.-bromoacetamido) cephalosporanic acid

LB Crast Jr, RG Graham…

Index: Crast,L.B. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 1413 - 1415

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Citation Number: 13

Abstract

Since the structural elucidation of cephalosporin C (1). 1.2 the discovery of ingenious and remarkably efficient chemical methods3-6 for its N-deacylation has rendered the novel fused dihydrothiazine-P-lactam nucleus, 7-aminocephalosporanic acid (7-ACA, 2), readily available for the synthesis of semisynthetic cephalosporins which now complement the penicillins in chemotherapeutic interest. 7