Bioorganic & medicinal chemistry

Comparative inhibitory activity of 3′-and 5′-functionalized nucleosides on ribonuclease A

J Debnath, S Dasgupta, T Pathak

Index: Debnath, Joy; Dasgupta, Swagata; Pathak, Tanmaya Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 23 p. 8257 - 8263

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Citation Number: 4

Abstract

Modified nucleosides, molecules, functionalized with various polar groups at different positions have been synthesized to rationalize the impact of structural modification on their inhibitory activity. Agarose gel and precipitation assays indicate their improved inhibitory activity on ribonuclease A (RNase A). Kinetic experiments clearly categorize them as competitive inhibitors of RNase A with improved inhibition constant (Ki) values (37±9, 67± ...