Tetrahedron letters

Mono C-alkylation and mono C-benzylation of barbituric acids through zinc/acid reduction of acyl, benzylidene, and alkylidene barbiturate intermediates

BS Jursic, ED Stevens

Index: Jursic, Branko S.; Stevens, Edwin D. Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2203 - 2210

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Citation Number: 44

Abstract

Through systematic exploration of reaction conditions, very efficient preparative procedures for obtaining large quantities of substituted 5-alkyl and 5-benzylbarbituric acids were developed. The procedure involves a two step preparation in which the second step is zinc dust/acid reduction. For preparation of 5-alkylbarbiturates, the first step is the preparation of either 5-acyl or 5-alkylidenebarbiturate. If 5-benzylbarbiturate is the target product, then ...

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