Development of 3, 5-dinitrobenzoate-based 5-lipoxygenase inhibitors

E Shang, Y Liu, Y Wu, W Zhu, C He, L Lai

Index: Shang, Erchang; Liu, Ying; Wu, Yiran; Zhu, Wei; He, Chong; Lai, Luhua Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2396 - 2402

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Abstract

Abstract Human 5-lipoxygenase (5-LOX) is a well-validated target for anti-inflammatory therapy. Development of novel 5-LOX inhibitors with higher activities is highly demanded. In previous study, we have built a model for the active conformation of human 5-LOX, and identified naphthalen-1-yl 3, 5-dinitrobenzoate (JMC-4) as a 5-LOX inhibitor by virtual screening. In the present work, 3, 5-dinitrobenzoate-based 5-lipoxygenase inhibitors were ...

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