Condensed pyrimidine systems. XX. Purines related to 6-mercaptopurine and thioguanine

GB Elion, I Goodman, W Lange…

Index: Elion et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 1898,1901

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Citation Number: 38

Abstract

The synthesis of potential antagonists of the nucleic acid bases has been under way in these laboratories for a number of With the finding that 6-mercaptopurine and 6-thioguanine are inhibitory to a number of transplantable animal tumors6-'* as well as to human le~ kemia,~~.~~ an extensive program was undertaken to study the relationship of chemical structure to antitumor activity among purines related to 6-mercaptopurine and 6- ...