The Journal of Organic Chemistry

A simple method for the synthesis of long-chain alkyl esters of amino acids

CL Penney, P Shah, S Landi

Index: Penney, Christopher L.; Shah, Pravinkant; Landi, Silvio Journal of Organic Chemistry, 1985 , vol. 50, # 9 p. 1457 - 1459

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Citation Number: 30

Abstract

A practical one step procedure is described for the synthesis of long-chain alkyl esters of amino acids. A number of octadecyl (stearyl) amino acids were made in moderate to high overall yields of 40-90% via methanesulfonic acid catalyzed esterification in an octadecanol melt. No special anhydrous conditions or N-protected amino acids were required and so in the case of lower product yields the synthesis was still desirable relative to alternative ...