Chemical Communications

JANUS WEDGES: a new approach towards nucleobase-pair recognition

N Branda, G Kurz, JM Lehn

Index: Branda, Neil; Kurz, Guido; Lehn, Jean-Marie Chemical Communications, 1996 , # 21 p. 2443 - 2444

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Citation Number: 19

Abstract

The two-faced JANUS-type heterocycles 1a and 1b are designed to recognize a cytosine– uracil mismatched basepair by insertion in a wedge-like fashion between the bases to give a triad motif utilizing the maximum number of Watson–Crick interactions, as shown by 1H NMR spectroscopic studies.