The synthesis and antiallergy activity of 1-(aryloxy)-4-(4-arylpiperazinyl)-2-butanol derivatives

DA Walsh, YH Chen, JB Green, JC Nolan…

Index: Walsh, David A.; Chen, Ying-Ho; Green, Jerry B.; Nolan, Joseph C.; Yanni, John M. Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1823 - 1827

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Citation Number: 7

Abstract

A series of l-(aryloxy)-4-(4-arylpiperazinyl)-2-butanol derivatives were prepared and evaluated for antiallergy activity in the passive foot anaphylaxis (PFA) assay in rats. Twenty- seven derivatives had activity equal to or greater than the parent, a-(phenoxymethyl)-4- phenyl-l-piperazinepropanol. Six derivatives that possessed greater activity in the PFA than the parent compound were then tested in the guinea pig anaphylaxis (GPA) assay. Five of ...