Tetrahedron Letters

A novel synthesis of coumarins employing triphenyl (α-carboxymethylene) phosphorane imidazolide as a C-2 synthon

PK Upadhyay, P Kumar

Index: Upadhyay, Puspesh K.; Kumar, Pradeep Tetrahedron Letters, 2009 , vol. 50, # 2 p. 236 - 238

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Citation Number: 24

Abstract

Because of the utmost significance of this heterocyclic system and their diverse pharmacological properties, many strategies for the synthesis of substituted coumarins have been developed. 3 Classical routes 4 to coumarins incorporate Pechmann, Knoevenagel, Perkin, Reformatsky and Wittig condensation reactions. However, most of these methods suffer from expensive catalyst, harsh reaction conditions, multistep synthesis or low chemical yield.

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