Synthesis and pharmacological evaluation of novel bisindolylalkanes analogues

…, T Yang, CC Zhang, LM Su, X Huang, DN Zhang…

Index: Song, Ya-Li; Dong, Yun-Fang; Yang, Tao; Zhang, Chao-Chao; Su, Li-Min; Huang, Xin; Zhang, Dong-Nuan; Yang, Geng-Liang; Liu, Yu-Xin Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 24 p. 7624 - 7627

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Citation Number: 7

Abstract

Abstract In an effort to develop potent anti-cancer chemopreventive agents that act on topoisomerase II, a novel series of bisindolylalkanes analogues such as 3, 3′-(thiochroman- 4, 4-diyl) bis (1H-indole) are synthesized. Structures of all compounds are elucidated by 1 H NMR, 13 C NMR and HRMS. Anti-proliferative activities for all of these compounds are investigated by the method of MTT assay on 7 human cancer lines. Most of them showed ...