Molecules

Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications

Y Zhou, P Yu, H Jin, Z Yang, J Yue, L Zhang, L Zhang

Index: Zhou, Yue; Yu, Peilin; Jin, Hongwei; Yang, Zhenjun; Yue, Jianbo; Zhang, Liangren; Zhang, Lihe Molecules, 2012 , vol. 17, # 4 p. 4343 - 4356

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Citation Number: 6

Abstract

Abstract: Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu (I)-catalyzed Hüisgen [3+ 2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane- permeating agonists of the calcium signaling pathway. The introduction of chlorine or ...