The Journal of organic chemistry

A diastereoselective radical cyclization approach to substituted quinuclidines

TA Hunt, AF Parsons, R Pratt

Index: Healy, Mark P.; Parsons, Andrew F.; Rawlinson, James G. T. Organic Letters, 2005 , vol. 7, # 8 p. 1597 - 1600

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Citation Number: 12

Abstract

A new, concise, and flexible approach to novel quinuclidines has been developed, which employs a phosphorus hydride mediated radical addition/cyclization reaction in the key step. 1, 7-Diene 5 reacts with diethyl thiophosphite in an efficient and diastereoselective radical