A new improved palladium-catalyzed amidocarbonylation

M Beller, WA Moradi, M Eckert, H Neumann

Index: Beller, Matthias; Moradi, Wahed A.; Eckert, Markus; Neumann, Helfried Tetrahedron Letters, 1999 , vol. 40, # 24 p. 4523 - 4526

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Citation Number: 29

Abstract

A new and improved variant of the palladium-catalyzed amidocarbonylation1) to yield N-acyl- α-aminoacids is described. Using Pd/C as catalyst the products were prepared in good to excellent yields (up to 98%). Advantages of the Pd/C-catalyst with regard to former catalyst systems are demonstrated by the preparation of N-substituted non-natural amino acids which are of current interest as structural units of peptoids.