Tetrahedron letters

A novel, thioacetal based linker for solid-phase synthesis

CM Huwe, H Künzer

Index: Huwe, Christoph M.; Kuenzer, Hermann Tetrahedron Letters, 1999 , vol. 40, # 4 p. 683 - 686

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Citation Number: 40

Abstract

Commercially available (±)-α-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiphenyls and 4- alkoxyacetophenones via Suzuki and Mitsunobu reactions, respectively. The products were easily cleaved from solid support by treatment with [bis (trifluoroacetoxy) iodo] benzene.

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