The Journal of organic chemistry

Synthesis of a new conformation-constrained L-Tyrosine analogue as a potential scaffold for SH2 domain ligands

F Liu, HY Zha, ZJ Yao

Index: Petragnani, Nicola; Yonashiro, Massami Synthesis, 1980 , # 9 p. 710 - 713

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Citation Number: 20

Abstract

... Synthesis. ... Refluxing succinic anhydride with tert-butyl alcohol for 24 h gave 4 9 as a colorless crystal, which was then reduced with borane 10 to afford the alcohol 5 (Scheme 2). Swern oxidation of 5 gave the aldehyde, which was immediately reacted with phosphonate 6 11 ...

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