Chemistry letters

Remarkable Effect of D-Sorbitol on the Second Stage in the PLE-Catalyzed Hydrolyses of a. SIGMA.-Symmetric Diester, cis-Cyclohex-4-ene-1, 2-bis (methyl acetate).

Y Nagao, T Tohjo, T Kaneuchi, Y Yukimoto, M Kume

Index: Nagao, Yoshimitsu; Tohjo, Toshiaki; Kaneuchi, Tohru; Yukimoto, Yusuke; Kume, Masaharu Chemistry Letters, 1992 , # 9 p. 1817 - 1820

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Citation Number: 5

Abstract

Enantioselective hydrolysis of cis-cyclohex-4-ene-1, 2-bis (methyl acetate) with porcine liver esterase (PLE) in the presence of D-sorbitol afforded a chiral monoester in a highly enantioselective manner. During the enzymatic hydrolyses, D-sorbitol efficiently accelerate the second stage; hydrolysis of the resultant minor monoester toward the dicarboxylic acid leaving the desired major monoester.

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