Asymmetric N H Insertion of Secondary and Primary Anilines under the Catalysis of Palladium and Chiral Guanidine Derivatives

…, S Dong, Y Zhou, W Li, L Lin, X Feng

Index: Zhu, Yin; Liu, Xiaohua; Dong, Shunxi; Zhou, Yuhang; Li, Wei; Lin, Lili; Feng, Xiaoming Angewandte Chemie - International Edition, 2014 , vol. 53, # 6 p. 1636 - 1640

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Citation Number: 31

Abstract

Abstract Efficient enantioselective N [BOND] H insertion reactions of secondary and primary anilines were catalyzed by palladium (0) in combination with chiral guanidine derivatives. A broad range of substituted anilines were tolerated, and the corresponding products were obtained in high yield (up to 99%) with good enantioselectivity (up to 94% ee) under mild reaction conditions. The N [BOND] H insertion mechanism was examined by the study of ...

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