Synthesis and antimicrobial evaluation of some chalcones and their derived pyrazoles, pyrazolines, isoxazolines, and 5, 6-dihydropyrimidine-2-(1H)-thiones

AH Adel, ES Ahmed, MAM Hawata, ER Kasem…

Index: Abdel-Rahman, Adel A.-H.; Abdel-Megied, Ahmed E.-S.; Hawata, Mohamed A. M.; Kasem, Eman R.; Shabaan, Mohamed T. Monatshefte fur Chemie, 2007 , vol. 138, # 9 p. 889 - 897

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Citation Number: 48

Abstract

Summary. Chalcones were synthesized by a base catalyzed Claisen-Schmidt condensation reaction. Bromination of chalcones afforded the dibromo derivatives. Monobromo derivatives could be obtained by treating the corresponding dibromochalcones with dry benzene in the presence of triethylamine. Pyrazole derivatives were obtained by refluxing of dibromochalcones with phenylhydrazine or 2, 4-dinitrophenylhydrazine in dry pyridine. ...