Microwave??Assisted Stereoselective One??Pot Synthesis of Symmetrical and Unsymmetrical 2, 5??Diketopiperazines from Unprotected Amino Acids
M Jainta, M Nieger, S Braese
Index: Jainta, Manuel; Nieger, Martin; Braese, Stefan European Journal of Organic Chemistry, 2008 , # 32 p. 5418 - 5424
Full Text: HTML
Citation Number: 18
Abstract
Abstract The facile condensation of unprotected amino acids by a phosphite-promoted one- step coupling reaction is a highly efficient synthesis to generate stereoselective and optically pure symmetrical and unsymmetrical functionalized diketopiperazines. The use of microwaves enhanced by small amounts of ionic liquid is accompanied by significant improvement in reaction times and yields. Simple filtration through a pad of silica provides ...
Related Articles:
[Qiao; Meutermans; Wong; Traubel; Wentrup Journal of the American Chemical Society, 1996 , vol. 118, # 16 p. 3852 - 3861]
[Qiao; Meutermans; Wong; Traubel; Wentrup Journal of the American Chemical Society, 1996 , vol. 118, # 16 p. 3852 - 3861]
[Qiao; Meutermans; Wong; Traubel; Wentrup Journal of the American Chemical Society, 1996 , vol. 118, # 16 p. 3852 - 3861]
[Gross, Gerhard; Wentrup, Curt Journal of the Chemical Society, Chemical Communications, 1982 , # 6 p. 360 - 361]
[Qiao; Meutermans; Wong; Traubel; Wentrup Journal of the American Chemical Society, 1996 , vol. 118, # 16 p. 3852 - 3861]