Amide Formation Using In Situ Activation of Carboxylic Acids with [Et2NSF2] BF4

O Mahé, J Desroches, JF Paquin

Index: Mahe, Olivier; Desroches, Justine; Paquin, Jean-Francois European Journal of Organic Chemistry, 2013 , # 20 p. 4325 - 4331

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Citation Number: 4

Abstract

Abstract The formation of amides through the in situ activation of carboxylic acids with [Et 2 NSF 2] BF 4 is presented. A wide range of carboxylic acids and amines were used to produce the corresponding amides in up to 99% yield. The reaction of hindered amines was also possible in the presence of 1, 8-diazabicyclo [5.4. 0] undec-7-ene (DBU) under slightly modified conditions. An enantiopure carboxylic acid and amine were both shown to react ...

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