Advanced synthesis & catalysis

A General and Practical Palladium??Catalyzed Direct α??Arylation of Amides with Aryl Halides

B Zheng, T Jia, PJ Walsh

Index: Zheng, Bing; Jia, Tiezheng; Walsh, Patrick J. Advanced Synthesis and Catalysis, 2014 , vol. 356, # 1 p. 165 - 178

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Citation Number: 26

Abstract

Abstract: An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong s indolebased phosphine ligand and provides monoarylated amides in up to 95% yield. Excellent chemoselectivities (> 10: 1) in the mono-and diarylation with aryl bromides were achieved by careful selection of bases, solvents, and stoichiometry. Under ...

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