Tetrahedron: Asymmetry

Asymmetric reductions of ketones using lithium aluminium hydride modified with N, N-dialkyl derivatives of (R)-(−)-2-aminobutan-1-ol

E Brown, A Penfornis, J Bayma, J Touet

Index: Brown, Eric; Penfornis, Annie; Bayma, Joaquim; Touet, Joeul Tetrahedron: Asymmetry, 1991 , vol. 2, # 5 p. 339 - 342

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Citation Number: 34

Abstract

Abstract LiAlH 4 previously treated with 2 equivalents of (R)-(−)-2-(2-iso-indolinyl) butan-1-ol (a readily available reagent) reduced 2-chloro and 2, 4-dimethyl benzophenones into the corresponding benzhydrols with 100% enantiomeric excess. Other examples of ketone reductions are given.

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