The Preparation of Some N-Carbethoxyamino Acids

MR Vernsten, MB Moore

Index: Vernsten; Moore Journal of the American Chemical Society, 1953 , vol. 75, p. 1320

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Citation Number: 7

Abstract

In the course of screening compounds for antiviral activity, it was found that N-carbobenzoxy and N-carbethoxyglycylaminomalonic acid diethyl esters seemed to have a slight virus inhibiting effect.'It appeared possible that the malonic ester residue was unnecessary and that the N-substituted amino acids were functioning as antimetabolites against essential amino acids. This theory was tested by the synthesis of N-carbethoxy derivatives of some ...