Sequential one-pot bimetallic Ir (III)/Pd (0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1, 3-dimethylbarbituric acid and allenes

…, A Keep, A Derrick, V Sridharan, C Kilner

Index: Loefberg, Christian; Grigg, Ronald; Keep, Ann; Derrick, Andrew; Sridharan, Visuvanathar; Kilner, Colin Chemical Communications, 2006 , # 48 p. 5000 - 5002

Full Text: HTML

Citation Number: 23

Abstract

Microwave assisted indirect functionalization of alcohols with 1, 3-dimethylbarbituric acid followed by spirocyclisation employing a sequential one-pot Ir (III)/Pd (0) catalysed process, involving the formation of three new C–C bonds, one spirocyclic ring and one di-or tri- substituted exocyclic alkene, is described.

Related Articles:

Mono C-alkylation and mono C-benzylation of barbituric acids through zinc/acid reduction of acyl, benzylidene, and alkylidene barbiturate intermediates

[Jursic, Branko S.; Stevens, Edwin D. Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2203 - 2210]

Development of Pharmaceutical Drugs, Drug Intermediates and Ingredients by Using Direct Organo??Click Reactions

[Ramachary, Dhevalapally B.; Kishor, Mamillapalli; Reddy, Y. Vijayendar European Journal of Organic Chemistry, 2008 , # 6 p. 975 - 993]

Reductive C-alkylation of barbituric acid derivatives with carbonyl compounds in the presence of platinum and palladium catalysts

[Jursic, Branko S.; Neumann, Donna M. Tetrahedron Letters, 2001 , vol. 42, # 25 p. 4103 - 4107]

Mono C-alkylation and mono C-benzylation of barbituric acids through zinc/acid reduction of acyl, benzylidene, and alkylidene barbiturate intermediates

[Jursic, Branko S.; Stevens, Edwin D. Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2203 - 2210]

Arene Hydrides, 10 Michael Additions of Anthracene Hydride. Selective Reduction of the ArC C Moiety by Fragmentation of the Michael Adduct

[Sommer, Andreas; Stamm, Helmut Liebigs Annalen der Chemie, 1992 , # 2 p. 99 - 102]

More Articles...