Tetrahedron Letters

Reductive C-alkylation of barbituric acid derivatives with carbonyl compounds in the presence of platinum and palladium catalysts

BS Jursic, DM Neumann

Index: Jursic, Branko S.; Neumann, Donna M. Tetrahedron Letters, 2001 , vol. 42, # 25 p. 4103 - 4107

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Citation Number: 32

Abstract

Effective synthetic procedures for the preparation of mono-and di-C-alkylated barbituric acid derivatives through palladium and platinum catalytic hydrogenation of solutions of barbituric acids (unsubstituted, N-mono, and N, N′-disubstituted barbituric acids) and carbonyl compounds (aliphatic and aromatic aldehydes and ketones).

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