Tetrahedron

An efficient enantioselective synthesis of indicine N-oxide, an antitumor pyrrolizidine alkaloid

T Ogawa, H Niwa, K Yamada

Index: Ogawa, Takeshi; Niwa, Haruki; Yamada, Kiyoyuki Tetrahedron, 1993 , vol. 49, # 8 p. 1571 - 1578

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Citation Number: 17

Abstract

Indicine N-oxide (1), a pyrrolizidine alkaloid potentially useful for an anticancer drug was synthesized in the natural form through regioselective coupling of (+)-retronecine (2) and the protected necic acids 16a and 16b, the latter being efficiently prepared from the optically pure lactone 5.

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