Cobalt complexes with tripodal ligands: implications for the design of drug chaperones

…, JK Clegg, P Turner, SM Neville, TW Hambley

Index: Bonnitcha, Paul D.; Kim, Byung J.; Hocking, Rosalie K.; Clegg, Jack K.; Turner, Peter; Neville, Suzanne M.; Hambley, Trevor W. Dalton Transactions, 2012 , vol. 41, # 37 p. 11293 - 11304

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Citation Number: 17

Abstract

Extensive research is currently being conducted into metal complexes that can selectively deliver cytotoxins to hypoxic regions in tumours. The development of pharmacologically suitable agents requires an understanding of appropriate ligand–metal systems for chaperoning cytotoxins. In this study, cobalt complexes with tripodal tren (tris-(2-aminoethyl) amine) and tpa (tris-(2-pyridylmethyl) amine) ligands were prepared with ancillary ...