Synthesis and antitrypanosomal evaluation of some thiazole-containing amino acids and peptides

…, W Bollaert, N Van Meirvenne, R Brun, K Smith…

Index: Van Bogaert; Haemers; Bollaert; Van Meirvenne; Brun; Smith; Fairlamb European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 387 - 397

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Citation Number: 6

Abstract

Abstract Several amino acids and peptides containing thiazole and thiazolidine residues were prepared. They were tested in vivo and in vitro as possible antitrypanosomal compounds. Some derivatives showed a slight activity. As they are structurally related to glutathione, their inhibitory properties towards glutathionylspermidine synthetase, trypanothione synthetase and trypanothione reductase were determined. No inhibitory ...