Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids

O Bortolini, G Fantin, M Fogagnolo, S Rossetti…

Index: Bortolini, Olga; Fantin, Giancarlo; Fogagnolo, Marco; Rossetti, Stefano; Maiuolo, Loredana; Di Pompo, Gemma; Avnet, Sofia; Granchi, Donatella European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 221 - 229

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Citation Number: 11

Abstract

Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases. A significant drawback of the BPs is their poor oral absorption that is enhanced by the presence of bile acid substituents in the bisphosphonate framework, with no toxic effects. A straightforward synthesis of bile acid-containing hydroxy-bisphosphonates and a full characterization of ...