Design and synthesis of novel 2H-chromen-2-one derivatives bearing 1, 2, 3-triazole moiety as lead antimicrobials

K Kushwaha, N Kaushik, SC Jain

Index: Kushwaha, Khushbu; Kaushik, Nagendra; Lata; Jain, Subhash C. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1795 - 1801

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Citation Number: 18

Abstract

Abstract A series of novel 2H-chromen-2-one derivatives decorated with 1, 2, 3-triazole moiety were designed and synthesized using the click reaction of azidoalkyloxy-2H- chromen-2-ones with different propargylamines. Propargylamines were obtained by alkylation of various heterocyclic amines with propargyl bromide. Newly synthesized compounds and intermediates were evaluated for their antifungal activity against four ...