Synthesis of aminomethyl and amino analogs of 5??benzylacyclouridine and 5??benzyloxybenzylacyclouridine

SH Chu, ZH Chen, ZY Weng, EC Rowe…

Index: Chu; Chen; Weng; et al. Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 4 p. 989 - 995

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Citation Number: 8

Abstract

Abstract Amino analogs of BAU (5-benzylacyclouridine) and BBAU (5- benzyloxybenzylacyclouridine) and their 2′-hydroxymethyl derivatives were synthesized for evaluation as inhibitors of uridine phosphorylase and hence potential cancer chemotherapeutic agents. Both aminomethyl analogs were found to be potent inhibitors of this enzyme and good potentiators of the anti-tumor action of FUdR.

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