Tetrahedron

The synthesis of (3, 4, 5, 6-tetrahydro-4-oxo-2h-1, 3-thiazin-2-yl)-alkanoic acids, their derivatives and some related compounds

J Nyitrai, J Fetter, G Hornyak, K Zauer, K Lempert…

Index: Nyitrai,J. et al. Tetrahedron, 1978 , vol. 34, p. 1031 - 1035

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Citation Number: 10

Abstract

5, 6-Dihydro-2H-1, 3-thiazin-4 (3H)-ones 2–10 related to the natural antituberculytic Mycobacidine 1, have been synthesised. Some of the compounds of types 2, 3 and 5 proved highly active in vitro against Mycobacterium tuberculosis typ. humanus (H37Rv), but the in vitro activities are diminished or suspended in the presence of biotine.