Palladium-Catalyzed Carbonylation with Mo (CO) 6 for the Synthesis of Benzoylacetonitriles

A Pyo, A Park, HM Jung, S Lee

Index: Pyo, Ayoung; Park, Ahbyeol; Jung, Hyunmin; Lee, Sunwoo Synthesis (Germany), 2012 , vol. 44, # 18 p. 2885 - 2888

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Citation Number: 7

Abstract

Abstract Benzoylacetonitriles were synthesized by the palladium-catalyzed carbonylation of aryl iodides and trimethylsilylacetonitrile using Mo (CO) 6 as a carbon monoxide source. Pd (PPh 3) Cl 2 and CuF 2 were employed as the catalyst and activator, respectively. A variety of aryl iodides bearing alkyl, alkoxy, fluoro, chloro, bromo, nitrile, ester, and ketone groups afforded the corresponding benzoylacetonitriles in moderate to good yields.