Journal of the American Chemical Society

The Nitration of 2-Hydroxy-5, 6-diphenylpyrazine and 2-Hydroxy-3, 6-diphenylpyrazine

G Karmas, PE Spoerri

Index: Karmas; Spoerri Journal of the American Chemical Society, 1953 , vol. 75, p. 5517

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Citation Number: 7

Abstract

2-Hydroxy-5, 6-diphenylpyrazine is readily nitrated in the 3-position. This was proved by degradation and by reduction to the correspondirrg hydroxyaminodiphenylpyrazine whose structure was demonstrated by two independent syntheses. It is shown that 2-hydroxy-3, 6- diphenylpyrazine is nitrated only under more vigorous conditions, yielding a variety of products.