4, 4-Dimethyl-1, 2, 3, 4-tetrahydroquinoline-based PPARα/γ agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural …

…, N Hennuyer, B Staels, V Audinot-Bouchez…

Index: Parmenon, Cecile; Guillard, Jerome; Caignard, Daniel-Henri; Hennuyer, Nathalie; Staels, Bart; Audinot-Bouchez, Valerie; Boutin, Jean-Albert; Dacquet, Catherine; Ktorza, Alain; Viaud-Massuard, Marie-Claude Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2683 - 2687

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Citation Number: 15

Abstract

Type-2 diabetes (T2D) is a complex metabolic disease characterized by insulin resistance in the liver and peripheral tissues accompanied by a deficiency in pancreatic β-cells. Since their discovery, three subtypes of peroxisome proliferator activated receptors have been identified, namely PPARα, PPARγ and PPARβ/(δ). In this study, we were interested in designing novel PPARγ selective agonists and/or dual PPARα/γ agonists. Based on the ...