Construction of the “Left Domain” of Haplophytine

KC Nicolaou, U Majumder, SP Roche…

Index: Nicolaou; Majumder, Utpal; Roche, Stephane Philippe; Chen, David Y.-K. Angewandte Chemie - International Edition, 2007 , vol. 46, # 25 p. 4715 - 4718

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Citation Number: 31

Abstract

Haplophytine (1, Figure 1) is an architecturally intriguing and synthetically daunting heterodimeric alkaloid endowed with insecticidal properties. Originally isolated in 1952 by Snyder and co-workers [1a–d] from the Mexican plant Haplophyton cimicidum, the structure of haplophytine was finally revealed in 1973 as a result of the pioneering studies of the groups of Cava,[1e, h] Yates,[1f, h] and Zacharias.[1f, g] The haplophytine molecule ...

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