Moulting hormones. LIII. The synthesis and biological activity of some ecdysone analogues
M Galbraith, DS Horn, B Kelly, J Kinnear…
Index: Galbraith; Horn; Kelly; et al. Australian Journal of Chemistry, 1981 , vol. 34, # 12 p. 2607 - 2618
Full Text: HTML
Citation Number: 12
Abstract
Abstract A number of ecdysone analogues were prepared to study the effect of structural changes on biological activity. It was found that analogues with the 5α-configuration or a 3, 5- cyclo structure were inactive, that a 3β-hydroxy group enhances activity but is not essential for activity, and that 3β-substituents decrease activity as follows: OMe (60%), OAc (25%) and OEt (10%). The keto diol (3), keto alcohol (9) and amide (36) were found to be highly toxic ...
Related Articles:
[Dolle; Hetru; Roussel; Rousseau; Sobrio; Luu; Hoffmann Tetrahedron, 1991 , vol. 47, # 34 p. 7067 - 7080]
[Dolle; Hetru; Roussel; Rousseau; Sobrio; Luu; Hoffmann Tetrahedron, 1991 , vol. 47, # 34 p. 7067 - 7080]
[Dolle; Hetru; Roussel; Rousseau; Sobrio; Luu; Hoffmann Tetrahedron, 1991 , vol. 47, # 34 p. 7067 - 7080]
[Dolle; Hetru; Roussel; Rousseau; Sobrio; Luu; Hoffmann Tetrahedron, 1991 , vol. 47, # 34 p. 7067 - 7080]
[Dolle; Hetru; Roussel; Rousseau; Sobrio; Luu; Hoffmann Tetrahedron, 1991 , vol. 47, # 34 p. 7067 - 7080]