Platelet aggregation inhibitors. 2. Inhibition of platelet aggregation by 5'-, 2-, 6-, and 8-substituted adenosines

K Kikugawa, K Iizuka, Y Higuchi…

Index: Kikugawa,K. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 387 - 390

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Citation Number: 35

Abstract

Several S'-alkyl (or ary1) thio-5'-deoxyadenosines have been synthesized from 3, 16917 but the preparation of 3 involves tedious steps because of its easy transformation into an N3, 5'- cycloadenosine derivative. 18 Thus, the method described above might be a readily accessible route for the preparation of 5'-alkyl (or ary1) thio-5'-deoxyadenosines, since la can be easily prepared from adenosine." 6-chloroinosine (4a) according to the method of ...