Bioorganic & medicinal chemistry letters

Substituted coumarins as esterase-sensitive prodrug moieties with improved release rates

Y Liao, B Wang

Index: Liao, Yuan; Wang, Binghe Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 13 p. 1795 - 1800

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Citation Number: 16

Abstract

Our laboratory has recently reported a coumarin-based prodrug system for the preparation of esterase-sensitive prodrugs of amines, peptides, and peptidomimetics. However, the release from this prodrug system was undesirably slow for some drug moieties. In this report, we describe the synthesis and evaluation of several substituted coumarin-based prodrugs of model amines with significantly increased release rates.

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