Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents

…, E Badaroux, R Storer, G Gosselin

Index: Pierra, Claire; Amador, Agnes; Badaroux, Eric; Storer, Richard; Gosselin, Gilles Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 7 p. 991 - 1010

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Citation Number: 12

Abstract

Abstract As part of our anti-hepatitis C program, we recently discovered 2'-C-methylcytidine (1) and 2'-C-methyluridine (2), which are potent inhibitors in cell culture of several viruses (bovine viral diarrhea virus (BVDV), yellow fever virus (YFV)) closely related to HCV. In order to characterize structure-activity relationships, we introduced some structural and functional modifications into the 3'-position of 2'-C-methylcytidine and 2'-C-methyluridine. All these ...

In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

[Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255]

In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents

Abstract

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