Regioselective One??Pot Synthesis of Isocoumarins and Phthalides from 2??Iodobenzoic Acids and Alkynes by Temperature Control
…, FM Irudayanathan, JH Moon, S Lee
Index: Kumar, Manian Rajesh; Irudayanathan, Francis Mariaraj; Moon, Joong Ho; Lee, Sunwoo Advanced Synthesis and Catalysis, 2013 , vol. 355, # 16 p. 3221 - 3230
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Citation Number: 13
Abstract
Abstract: Copper-catalyzed coupling reaction of 2-iodobenzoic acids and alkynes such as terminal acetylenes, alkynyl carboxylic acids, and trimethylsilylacetylene selectively afforded isocoumarins and phthal-ACHTUNGTRENNUNGides in the presence of cesium carbonate (Cs2CO3) and dimethyl sulfoxide (DMSO). Among the regioselective products, only the 6- endo-dig product, isocoumarin, was formed at 1008C, and the 5-exo-dig product, ...
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