Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

EJ Hennessy, JC Saeh, L Sha, T MacIntyre…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1690 - 1694

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Citation Number: 7

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... in the Smac binding groove (eg, the hydrophobic pockets occupied by the methyl side chain of the alanine residue and the sec-butyl side chain of the isoleucine residue) have been described in the patent and chemical literature. ...